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The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas
QIN Xinyu, LIU Fenglin
《医学前沿(英文)》 2007年 第1卷 第2期 页码 121-125 doi: 10.1007/s11684-007-0023-5
关键词: available additional existence necessitate intraductal papillary non-invasive
LOU Wenhui, JIN Dayong, WANG Dansong, XU Xuefeng, KUANG Tiantao, QIN Xinyu
《医学前沿(英文)》 2007年 第1卷 第2期 页码 173-176 doi: 10.1007/s11684-007-0032-4
关键词: diameter Pathologic rereview invasive unresectable intraductal papillary
Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 113-117 doi: 10.1007/s11684-014-0310-x
Papillary thyroid carcinoma (PTC) is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained (C vs. T, P=0.027, OR=1.264, 95% CI=1.026-1.557; and C/C-C/T vs. T/T, P=0.034, OR=1.474, 95% CI=1.028-2.112). Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 (adjusted P=0.062) between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction (P=0.029; OR=2.578, 95% CI=1.104-6.023) between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.
关键词:
甲状腺乳头状癌菌群失调及与肿瘤信号通路异常的相关性研究 Article
喻爽, 丁彦强, 王雪洁, Siu Kin Ng, 曹思婷, 刘伟鑫, 郭朱明, 谢宇彬, 洪澍彬, 许丽霞, 李晓星, 李杰, 吕伟明, 彭穗, 李延兵, 沈祖尧, 于君, 肖海鹏
《工程(英文)》 2023年 第28卷 第9期 页码 179-192 doi: 10.1016/j.eng.2023.01.007
研究表明微生态失调在多种肿瘤的发生发展中起至关重要的作用。然而,对于甲状腺肿瘤中细菌是否参与肿瘤的发生仍不清楚。本研究中,我们旨在探索甲状腺组织中的菌群特征及其对甲状腺乳头状癌(PTC)的作用。我们同时对 340 例PTC和甲状腺良性结节 (BTN) 患者的肿瘤组织及其邻近正常组织进行菌群分析和转录组测序。在PTC、BTN及其邻近无肿瘤组织中鉴定出明显不同的菌群特征。我们通过免疫组化染色、细菌原位杂交和电镜观察验证了甲状腺组织内细菌的存在。与BTN相比,我们发现在PTC中有17个菌属存在显著丰度差异,其中PTC中富集菌Rhodococcus、Neisseria、Streptococcus、Halomonas和Devosia存在促癌作用;以及丰度降低的Amycolatopsis则可能有抑癌作用。这些丰度存在明显差异的细菌可以鉴别PTC组织(PTC-T)与BTN组织(BTN-T),曲线下面积(AUC)为81.66%。微生物网络分析表明,PTC组织内细菌间的相互关联性高于BTN组织。同时,在合并桥本甲状腺炎组织的PTC中发现与免疫相关的菌属(Erwinia、Bacillus 和 Acinetobacter)明显富集。此外,我们联合转录组测序分析提示PTC富集菌与肿瘤相关信号通路的关键基因如BRAF、KRAS、IRAK4、CTNNB1、PIK3CA、MAP3K7 和 EGFR存在正相关性。总的来说,我们的研究结果表明,甲状腺肿瘤组织内存在菌群失调,并可能通过肿瘤相关信号通路参与PTC的发生。
标题 作者 时间 类型 操作
The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas
QIN Xinyu, LIU Fenglin
期刊论文
An analysis of clinico-pathologic features of intraductal papillary mucinous neoplasm of the pancreas
LOU Wenhui, JIN Dayong, WANG Dansong, XU Xuefeng, KUANG Tiantao, QIN Xinyu
期刊论文
Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern
null
期刊论文